The Rx-like Homeobox Gene (Rx-L) Is Necessary for Normal Photoreceptor Development

The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene.

The eyeless inbred mouse strain ZRDCT has long served as a spontaneous model for human anophthalmia and the evolutionary reduction of eyes that has occurred in some naturally blind mammals. ZRDCT mice have orbits but lack eyes and optic tracts and have hypothalamic abnormalities. Segregation data suggest that a small number of interacting genes are responsible, including at least one major rece...

Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development.

Vertebrate and invertebrate eye development require the activity of several evolutionarily conserved genes. Among these the Pax-6 genes play a major role in the genetic control of eye development. Mutations in Pax-6 genes affect eye development in humans, mice, and Drosophila, and misexpression of Pax-6 genes in Drosophila can induce ectopic eyes. Here we report the identification of a paired-l...

The homeobox gene Lbx1 specifies a subpopulation of cardiac neural crest necessary for normal heart development.

Cardiac neural crest cells are known to play multiple roles during development of the inflow and outflow tract of the heart and the aortic arch. In addition, cardiac neural crest is required for normal heart tube looping and regulation of myocardial cell proliferation, as well as differentiation and function of the myocardium. We show that the homeobox gene Lbx1 is expressed in a subpopulation ...

Rx for Semantics∗

A constructive framework of recent work in the semantics of programming languages is offered. The criticism is directed not so much at the techniques and results obtained as at the use to which they are put. The fact that denotational (or “mathematical”) semantics plays on the whole a passive (“descriptive”) rôle, while operational semantics plays on the whole an active (“prescriptive”) rôle, i...

Rx: forgiveness.